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Acupuncture for Bladder & Urinary Tract Conditions.
Numerous conditions can affect the bladder and other parts of the urinary tract, with some specific to men, others to women, and some affecting both sexes.
Symptoms of overactive bladder and recurrent UTIs can greatly affect the quality of life of those affected.
Always seek prompt medical advice if you notice blood in the urine, pain on urination, inability to urinate or uncontrollable urine flow. If left untreated, urinary problems can lead to more serious kidney damage.
What does the research say?
The following insights are obtained from systematic reviews and analysis of clinical trials investigating the efficacy of Chinese medicine and acupuncture for bladder & urinary tract conditions.
2023 Journal of Ethnopharmacology
The herbal decoction Jian-Pi-Yi-Shen reduces symptoms of chronic kidney disease and anaemia by improving iron metabolism and inhibiting the JAK2-STAT3 signaling pathway.
Methodology used included an analysis of network pharmacology, chemical profiling, and in vivo experiments on the effect of Jian-Pi-Yi-Shen (JPYS) on renal anemia and chronic kidney disease (CKD). The active compounds in JPYS were detected in in vivo experiment, and their potential targets were predicted by network pharmacology. An animal model of CKD-related anemia was developed using adenine-feeding for further analysis. The estimation of renal injury was conducted using blood tests, histopathological examinations, and fibrosis degree assessment while the levels of JAK2, STAT3 and iron metabolism-related factors were measured through various techniques.
Discussion of the results reveals that 164 active ingredients, including prototypes and metabolites in JPYS, were discovered and 21 core targets were identified. Many of these core targets were associated with the JAK2-STAT3 signaling pathways. Experimental results demonstrated that JPYS treatment significantly improved hematological parameters and iron metabolism in CKD rats, decreased certain indicators of renal damage, and suppressed the expression of JAK2 and STAT3.
Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy Li C, Huang H, Wang R, Zhang C, Huang S, Wu J, Mo P, Yu H, Li S, Chen J
2022 Frontiers in Pharmacology
The Jian Pi Yi Shen formula in traditional Chinese medicine demonstrates a protective effect on kidneys by modulating tryptophan metabolism and Aryl hydrocarbon receptor activation.
A chronic kidney disease (CKD) rat model was induced by feeding a diet containing 0.75% adenine over a four-week period. Concurrently, the Jian-Pi-Yi-Shen formula was administered every day starting from the third week and continued for four additional weeks. Multiple factors were evaluated including renal injury, fibrotic markers expression, and serum creatinine and blood urea nitrogen levels. The levels of 10 tryptophan metabolites in the rat serum and Aryl hydrocarbon receptor signaling were detected and analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry and Western blot analysis, respectively.
The Jian-Pi-Yi-Shen formula demonstrated significant effects of reducing both serum creatinine and blood urea nitrogen levels and improving renal pathological injuries in the CKD rat model. It was found that the formula also regulated tryptophan metabolism and decreased the levels of tryptophan metabolites in the serum. Furthermore, the formula suppressed the overactivated Aryl hydrocarbon receptor signaling in the kidney. These observations imply that the actions of the Jian-Pi-Yi-Shen formula could effectively protect against CKD.
Jian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling Liu X, Deng R, Chen Y, Huang S, Lu J, Zheng L, Xiong G, Li S
2022 Clinical Phytoscience
Pumpkin seed extract treatment could potentially offer symptomatic relief for patients experiencing moderate lower urinary tract symptoms suggestive of benign prostate hyperplasia.
The study methodology involved a meta-analysis of two separate studies that were randomized and placebo-controlled, focusing on the effectiveness of pumpkin seed extract in addressing urinary tract symptoms indicative of benign prostate hyperplasia. The participants included in these studies were those patients whose International Prostate Symptom Score was 13 points or higher at the baseline. The method of analysis involved assessing the response rates of patients and the improvement in prostate symptom scores at a 12-month follow-up.
The discussion of results revealed that the response rates in the group receiving pumpkin seed extract were marginally higher than that of the placebo group, giving pumpkin seed extract a slight edge. Additionally, there was a minor difference observed in the change from the baseline to 12-month Prostate Symptom Score in favour of pumpkin seed extract. The meta-analysis in general indicates that a treatment involving pumpkin seed extract may result in symptomatic relief for patients suffering from moderate urinary tract symptoms associated with benign prostate hyperplasia.
Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months Vahlensieck W, Heim S, Patz B, Sahin K
2021 Medicine
Acupuncture can effectively improve the post voided residual urine, maximal cystometric capacity, and bladder capacity for first voiding desire values of patients with urinary retention after hysterectomy.
There is insufficient evidence that acupuncture can increase the patient's MFR, BR, and UIR. However, acupuncture can effectively improve the PVR, maximal cystometric capacity, and bladder capacity for first voiding desire values of patients with urinary retention after hysterectomy. Although limited due to the quality and methodological limitations of the included studies, acupuncture can still be used as an effective and safe treatment for women with urinary retention after hysterectomy.
Efficacy and safety of acupuncture for urinary retention after hysterectomy Zhao Q, Yan C, Dan M, Jia H
2021 Medicine
Acupuncture can effectively improve the post voided residual urine, maximal cystometric capacity, and bladder capacity for first voiding desire values of patients with urinary retention after hysterectomy.
There is insufficient evidence that acupuncture can increase the patient's MFR, BR, and UIR. However, acupuncture can effectively improve the PVR, maximal cystometric capacity, and bladder capacity for first voiding desire values of patients with urinary retention after hysterectomy. Although limited due to the quality and methodological limitations of the included studies, acupuncture can still be used as an effective and safe treatment for women with urinary retention after hysterectomy.
Efficacy and safety of acupuncture for urinary retention after hysterectomy Zhao Q, Yan C, Dan M, Jia H
2021 The Brazilian Journal of Nursing
Acupuncture has a positive effect in improving quality of life, fatigue and sleep in patients with chronic kidney disease.
Nine studies were selected; the acupuncture techniques used were auriculotherapy, electroacupuncture and acupressure aimed at improving quality of life, fatigue, sleep and clinical variables of the disease. The studies that assessed quality of life, sleep and fatigue presented significant benefits. Studies that assessed quality of life, sleep and fatigue presented significant benefits. There was no statistical significance in the improvement of serum creatinine levels and glomerular filtration rate. Methodological and assessment tools’ divergence made impossible meta-analysis.
Effects of acupuncture in patients with chronic kidney disease: a systematic review Melo GAA, Aguiar LL, Silva RA, Pereira FGF, Silva FLBD, Caetano JÃ.
2021 Frontiers in Pharmacology
Luteolin, a component of traditional Chinese medicine herb Zi Su Ye, has been found to alleviate kidney disease stage 3-5 by reducing renal tubular epithelial cell apoptosis.
By using network pharmacology, the research identified the active components of a traditional Chinese medicine herb used for treating chronic kidney disease stages 3-5. Active components were analyzed using high performance liquid chromatography and enriched for substantial analysis. Thereafter, critical components were verified using molecular docking and experimentations. The key therapeutic targets were observed from a constructed PPI network, and further focused on five core nodes: AKT1, TP53, IL6, TNF, and MAPK1.
In discussing the results, it was revealed that 19 active components were recognized, interlinking with 108 targets of chronic kidney disease stages 3-5. The potential regulation of various biological functions by these targets was suggested. Specifically, apoptosis, T cell receptor, and PI3K-AKT signaling pathways would be modulated. Molecular docking supported the premise that active components dock successfully with corresponding targets. Luteolin emerged as the most effective component in managing adriamycin-induced renal tubular apoptosis by affecting oxidative stress and downgrading the MAPK and p53 pathways.
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology Yong C, Zhang Z, Huang G, Yang Y, Zhu Y, Qian L, Tian F, Liu L, Wu Q, Xu Z, Chen C, Zhao J, Gao K, Zhou E
2021 Nutrients
Extra virgin olive oil high in minor polar compounds significantly improves kidney function, reduces oxidative stress, inflammation, and ultimately benefits the body composition.
The research study tested two distinct types of extra virgin olive oils, namely Synergy with a high content and Luxolio with a medium content of minor polar compounds, on 40 patients suffering from kidney disease. The patients were administered a 40 mL dosage per day over nine weeks. Researchers assessed the impacts on renal functionality, oxidative stress, inflammation levels, and body composition, before and after a subsequent two-month wash out period. Additionally, the concentration of minor polar compounds in the oils was determined through high-performance liquid chromatography accompanied by diode-array detection and mass spectrometry (HPLC-DAD-MS).
The research showed improvements in kidney function indicators such as estimated glomerular filtration rate, albuminuria, azotemia, and uric acid. Further, the patients' lipid profile also improved, as did their inflammation parameters, erythrocyte sedimentation rate, C-reactive protein, and body composition. More notably, these beneficial effects were stronger and lasted longer in those patients who had been given the Synergy oil, indicating a sustained antioxidant and anti-inflammatory impact from EVOOs with higher concentrations of minor polar compounds.
Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients Noce A, Marrone G, Urciuoli S, Di Daniele F, Di Lauro M, Pietroboni Zaitseva A, Di Daniele N, Romani A
2021 BMC Urology
Pumpkin seed oil can alleviate symptoms of benign prostatic hyperplasia with no side effects, though not as efficiently as tamsulosin.
In this single-blind randomized clinical trial, patients aged 50 years or above suffering from benign prostatic hyperplasia were included. These patients were divided into two groups, with one group being administered tamsulosin nightly and the other receiving pumpkin seed oil twice a day. Variables such as age, weight, height and body mass index of the patients were taken into account. The international prostate symptom score was noted for each patient at the start, then after one and three months into the treatment. Other factors recorded include the quality of life associated with BPH, prostate-specific antigen serum, prostate and postvoid residual volume and maximum urine flow. Information regarding any drug side effects was also recorded.
Following a comparison of the two groups, it was observed that there was no significant difference in principal variables at any point during the trial. However, both groups saw a notable reduction in the international prostate symptom score and an improvement in quality of life. The decrease was comparatively more significant in the tamsulosin group after one and three months. Patients administered pumpkin seed oil experienced no side effects, unlike those in the tamsulosin group who experienced dizziness, headaches, retrograde ejaculation and erythema with pruritus.
Pumpkin seed oil (Cucurbita pepo) versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial Zerafatjou N, Amirzargar M, Biglarkhani M, Shobeirian F, Zoghi G
2021 Scientific Reports
Lower testosterone levels in aging men correlate with a larger prostate volume.
The study analysed the relationship between testosterone levels and prostate size in aging, overtly healthy males. Data was collected from 416 men who underwent routine health exams and these individuals were revisited after a span of four years. Variables not only included testosterone levels and prostate size, but also examined associated obesity-related factors such as waist circumference, body mass index, and insulin levels.
The analysis focused on drawing correlations between various factors. Specifically, comparisons were made between men with lower testosterone levels and larger prostate sizes, and those with normal testosterone levels. Both initial prostate sizes and the change in size over the four-year period were evaluated in conjunction with testosterone levels. The role of testosterone levels was further intricately reviewed by adjusting for the age factor, to understand how this relationship may change over time.
In investigating the results, it was observed that men with lower testosterone did tend to have significantly larger prostates, and higher levels of obesity-related factors compared to those with normal testosterone levels. It was also found that there was a negative correlation between testosterone levels and prostate size, that is, as testosterone increased, prostate size showed a substantial decreasing trend.
Relationship between serum total testosterone and prostate volume in aging men Xia BW, Zhao SC, Chen ZP, Chen C, Liu TS, Yang F, Yan Y
2021 Journal of Renal Nutrition
Consuming coffee is associated with lower risks of developing chronic kidney disease, reaching end-stage kidney disease, and having albuminuria.
In this systematic review and meta-analysis, researchers conducted a comprehensive literature search through various databases, including PubMed/Medline, Web of Science, Embase by Elsevier, and the Cochrane Central Register of Controlled Trials by Wiley from 1960 until February 2020. Outcomes related to chronic kidney disease incidence, its progression, and mortality associated with this disease were evaluated and correlated with coffee consumption and the amount consumed. Quality assessment of the included studies was done using the Newcastle-Ottawa scale.
The analysis incorporated 12 studies, with a mix of prospective and cross-sectional studies, and a total of 505,841 subjects. Seven of these studies focused on the relationship between coffee consumption and the onset of chronic kidney disease. The finding was that consuming coffee was significantly correlated with a decrease in the risk for this disease, especially for individuals who took more than 2 cups of coffee per day. Furthermore, there was also a noteworthy lower risk of reaching end-stage kidney disease for coffee drinkers, as well as a decrease in the risk of albuminuria (a kidney disease marker). Finally, the risk of death related to chronic kidney disease was discovered to be lower in coffee consumers.
Effect of Coffee Consumption on Renal Outcome: A Systematic Review and Meta-Analysis of Clinical Studies Kanbay M, Siriopol D, Copur S, Tapoi L, Benchea L, Kuwabara M, Rossignol P, Ortiz A, Covic A, Afsar B
2020 BJOG: An International Journal of Obstetrics & Gynaecology
Acupuncture appeared to be beneficial for treatment and prophylaxis of recurrent urinary tract infections.
Five RCTs involving 341 participants were included. Methodological quality of studies and strength of the evidence were low to moderate. The chance of achieving a composite cure with acupuncture therapies was greater than that with antibiotics. The risk of UTI recurrence was lower with acupuncture than with no treatment and sham acupuncture.
Acupuncture appeared to be beneficial for treatment and prophylaxis of recurrent urinary tract infections, noting the limitations of the current evidence. Given the growing challenge of antibiotic resistance, there is a need for high-quality RCTs of non-pharmacological interventions such as acupuncture.
Acupuncture for recurrent urinary tract infection in women: a systematic review and metaâ€analysis Qin X, Coyle ME, Yang L, Liang J, Wang K, Guo X, Zhang AL, Mao W, Lu C, Xue CC, Liu X
2020 Evidence-Based Complementary and Alternative Medicine
Jian-Pi-Yi-Shen, a traditional Chinese medicine, helps treat anemia in chronic kidney disease by stimulating erythropoietin production and regulating iron recycling.
To investigate the effect of Jian-Pi-Yi-Shen (JPYS), chronic kidney disease (CKD) was experimentally induced in rats using a 5/6 nephrectomy. The rats were then administered JPYS orally in both high and low doses for a period of 90 days. Observations were made regarding the serum hepcidin level to assess iron homeostasis. Additionally, the protein expressions of hypoxia inducible factor-2, erythropoietin, ferritin, ferroportin, and the phosphorylation level of extracellular signal-regulated kinase 1/2 were studied using Western blot analysis.
The results showed that JPYS treatment significantly improved kidney function in the CKD rats. Alongside this, pathological kidney damage was found to be significantly restored post-JPYS treatment. The medicine was found to be effective in improving anemia in CKD through the upregulation of red blood cells, hemoglobin, and hematocrit levels. It was also discovered that JPYS stimulates the expressions of erythropoietin and hypoxia-inducible factor-2 proteins in the kidney and liver of the CKD rats, while inducing the phosphorylation of extracellular signal-regulated kinase 1/2 proteins. Furthermore, JPYS was seen to regulate the protein expressions of ferritin and ferroportin in the liver and spleen, as well as in the serum level of hepcidin, suggesting its role in systemic iron recycling.
Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling Wang F, Yu H, Huang S, Zheng L, Zheng P, Zhang S, Li S, Chen J
2019 Acupuncture in Medicine
Meta-analysis showed that acupuncture was comparable to drugs in the reduction of overactive bladder symptoms.
Seven eligible trials involving 695 participants were included. Meta-analysis showed that acupuncture was comparable to drugs (tolterodine tartrate/solifenacin) in the reduction of micturition episodes over 24 hours, increase in voided volume of each micturition episode, and reduction of overactive bladder symptom score. In addition, acupuncture was not significantly different compared with placebo in the reduction of overactive bladder symptom score. No serious adverse events were reported.
Acupuncture for overactive bladder in adults: a systematic review and meta-analysis Mak TC, Chen HY, Cho WC
2018 Medicine
Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes.
Overactive bladder is stated as the occurrence of urinary urgency which will cause negative impacts and decrease patients’ health-related quality of life. The aim of this systematic review is to assess the efficiency and safety of acupuncture for adults with overactive bladder (OAB) comparing with sham-acupuncture, drugs, and acupuncture plus drugs.
Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes. However, the evidence is insufficient to show the effect using acupuncture alone or the additional effect to drugs in treating OAB.
Acupuncture for adults with overactive bladder: A systematic review and meta-analysis of randomized controlled trials Zhao Y, Zhou J, Mo Q, Wang Y, Yu J, Liu Z.
2018 Medicine
Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes.
According to the results of meta-analysis, acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes. However, the evidence is insufficient to show the effect using acupuncture alone or the additional effect to drugs in treating OAB. Nevertheless, acupuncture is comparatively with few adverse reactions and safe. In the future, studies with high methodological quality and larger sample sizes are required.
Acupuncture for adults with overactive bladder Zhao Y, Zhou J, Mo Q, Wang Y, Yu J, Liu Z
2018 Medicine
Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes.
According to the results of meta-analysis, acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes. However, the evidence is insufficient to show the effect using acupuncture alone or the additional effect to drugs in treating OAB. Nevertheless, acupuncture is comparatively with few adverse reactions and safe. In the future, studies with high methodological quality and larger sample sizes are required.
Acupuncture for adults with overactive bladder Zhao Y, Zhou J, Mo Q, Wang Y, Yu J, Liu Z
2018 The Journal of Internal Korean Medicine
Moxibustion was found to be an effective and safe treatment improving symptoms and quality of life in patients with Benign Prostatic Hyperplasia.
The study used a randomized controlled trial method, comparing the effects of moxibustion and placebo treatment on Benign Prostatic Hyperplasia. Participants were divided into two groups: one that received the moxibustion treatment on specific acupuncture points, and another placebo group that received a sham treatment mimicking moxibustion without therapeutic effect. Outcome measures assessed were International Prostate Symptom Score, maximum urinary flow rate, quality of life index, and occurrence of adverse events.
The study found significant improvements in the moxibustion group in regards to the measured prostate symptom score and urinary flow rate when compared to the placebo group. The quality of life index was also significantly higher for the moxibustion group. Moreover, adverse events were rare and mild in both participant groups.
Moxibustion for Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis Bae G, Lee S, Hong J, Lee I, Kim S, Choi J, Han C, Yun Y, Park S, Kwon J
2017 PLOS One
Acupuncture can significantly improve urological symptoms in the short term for men with benign prostatic hyperplasia.
The comprehensive study used a systematic review and a meta-analysis to measure both the therapeutic and adverse effects of acupuncture on benign prostatic hyperplasia (BPH) through randomized controlled trials. Independent reviewers analyzed and extracted data from various renowned databases including MEDLINE, EMBASE, The Cochrane Library, and several Chinese knowledge resources. The trials focused on BPH symptomatic men and reviewed the extent to which acupuncture treatment altered urological symptoms.
The results from eight separate randomized controlled trials involving 661 men were combined, showing statistical short-term (4-6 weeks) improvement in urological symptoms for BPH patients through the use of acupuncture. However, the medium-term follow-up (12-18 weeks) analysis did not indicate any significant effect. The beneficial effects were considerably noticeable in cases of moderate to severe BPH on the short-term follow-up endpoints. Nonetheless, the clinical significance of these changes necessitates rigorous and long-term follow-ups for validation.
Acupuncture for benign prostatic hyperplasia: A systematic review and meta-analysis Zhang W, Ma L, Bauer BA, Liu Z, Lu Y
2016 International Urogynecology Journal
Some comparative trials showed the benefit of acupuncture to be comparable with antimuscarinic treatment for overactive bladder.
Initial animal studies suggest several biochemical mechanisms of action underlying the effect of acupuncture on overactive bladder (OAB) suppression. The experience in humans includes two case series and six comparative trials. All studies demonstrated subjective improvement in OAB symptoms, and some reported objective improvement in urodynamic studies. Notably, some comparative trials showed the benefit of acupuncture to be comparable with antimuscarinic treatment.
Despite their limitations, existing studies serve as a promising foundation for suggesting a role for acupuncture as an alternative therapy for OAB. Further well-designed studies are required to investigate optimal technique and their outcomes.
The role of acupuncture in managing overactive bladder; a review of the literature Forde JC, Jaffe E, Stone BV, Te AE, Espinosa G, Chughtai B.
2015 Evidence-Based Complementary and Alternative Medicine
We cautiously suggest that acupuncture therapy could demonstrate better clinical efficacy than pharmacological treatment or placebo treatment in treating nocturnal enuresis.
In summary, the results of this study suggest that acupuncture therapy demonstrate better clinical efficacy than pharmacological treatment or placebo treatment in treating NE. Due to the low methodological qualities of included trials, the findings of current study should be interpreted with caution. Therefore, to further assess the potential beneficial effect of acupuncture therapy for NE, additional RCTs with rigorous experimental design, large-scale high quality methodological control, long follow-ups, and strict reporting specification are required.
Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lv ZT, Song W, Wu J, et al.
2015 Cochrane Database of Systematic Reviews
Chinese herbal medicine may provide an effective treatment during the acute phase of UTI and when given prophylactically to prevent recurrence in the six months following treatment.
We found limited evidence from seven RCTs about the possible role of Chinese herbal medicine as a treatment for recurrent UTI, either as the sole intervention or as an adjunct to antibiotic treatment for postâ€menopausal women. CHM may provide an effective treatment during the acute phase of UTI and when given prophylactically to prevent recurrence in the six months following treatment. However, the small number and poor quality of the included studies meant that it was not possible to formulate robust conclusions on the use of CHM for recurrent UTI in women, when administered alone or as an adjunct to antibiotics.
Chinese herbal medicine for treating recurrent urinary tract infections in women Flower A, Wang LQ, Lewith G, Liu JP, Li Q.
2013 Asian Journal of Andrology
Chinese herbal medicine appears to be more effective than Western medication in improving quality of life and reducing prostate volume in benign prostatic hyperplasia patients.
The method utilized in this research involved the systematic review of randomized controlled trials from diverse electronic databases. These trials were focused on comparing Chinese herbal medicine, in standalone or supplementary use with Western medication, against placebo or solely Western medication. All trials reviewed pertained to benign prostatic hyperplasia. Outcomes measured included changes in patients' urological symptoms, urodynamic measures, prostate volume and the occurrence of adverse events.
The analysis revealed that Chinese herbal medicine was superior to Western medicines in terms of improving patients' quality of life as well as reducing the size of the prostate. Furthermore, the occurrence and frequency of adverse events in patients treated with Chinese herbal medicines were found to be similar to those observed in placebo groups and lesser compared to groups treated with Western medication. However, due to the limited number of trials and their methodological quality, the evidence supporting the efficacy of Chinese herbal medicine remains weak.
Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials Ma CH, Lin WL, Lui SL, Cai XY, Wong VT, Ziea E, Zhang ZJ
Consult with our practitioners for personalised care and advice.
Although well-conducted clinical research can help members of the public to make better-informed decisions about their healthcare, we cannot claim that any particular treatment may be effective for any individual person.
When you consult with our Chinese medicine practitioners, you'll receive personalised advice and treatment based on your symptoms and Chinese medicine diagnosis.
Scientific References
Browse our collection of scientific clinical research on acupuncture for bladder & urinary tract conditions.
It includes recent and reputable papers published by peer-reviewed journals within the last 10 years.
![Journal of Ethnopharmacology Journal of Ethnopharmacology](https://clinix.io/research/journal-covers/journal-267.png)
2023, Aug
Jian-Pi-Yi-Shen formula restores iron metabolism from dysregulation in anemic rats with adenine-induced nephropathy
Journal of Ethnopharmacology
Jian-Pi-Yi-Shen (JPYS) reduces hepcidin levels by inhibiting JAK2-STAT3 signaling, thereby improving iron metabolism and alleviating renal anemia in CKD rats. Experimental results demonstrated improvements in renal function, histopathological damage, and hematological parameters following JPYS treatment.
Li C, Huang H, Wang R, Zhang C, Huang S, Wu J, Mo P, Yu H, Li S, Chen J Full Article
![Frontiers in Pharmacology Frontiers in Pharmacology](https://clinix.io/research/journal-covers/journal-126.png)
2022, Jul 05
Jian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling
Frontiers in Pharmacology
The results found that JPYSF treatment significantly lowered Scr and BUN levels, improved renal pathological injury, and down-regulated fibrotic markers expression in CKD rats. Furthermore, JPYSF significantly reduced the levels of 10 tryptophan metabolites in the serum of CKD rats and restored the level of tryptophan. Additionally, the kidney expression of AHR signaling was enhanced in CKD rats and was further suppressed in JPYSF treated rats. These results suggested that JPYSF protected against adenine-induced CKD via modulating tryptophan metabolism and AHR activation.
Liu X, Deng R, Chen Y, Huang S, Lu J, Zheng L, Xiong G, Li S Full Article
![Clinical Phytoscience Clinical Phytoscience](https://clinix.io/research/journal-covers/journal-859.png)
2022, Apr 13
Beneficial effects of pumpkin seed soft extract on lower urinary tract symptoms and quality of life in men with benign prostatic hyperplasia: a meta-analysis of two randomized, placebo-controlled trials over 12 months
Clinical Phytoscience
The meta-analysis, incorporating patient-level data from the Bach and GRANU studies, suggests that, despite contradictory results in individual trials, PSE demonstrates an advantage over placebo, with a higher percentage of patients in the PSE group showing an International Prostate Symptom Score (IPSS) improvement of at least 5 points after 12 months. This implies potential symptomatic relief for patients with moderate LUTS/BPH through PSE treatment.
Vahlensieck W, Heim S, Patz B, Sahin K Full Article
![Medicine Medicine](https://clinix.io/research/journal-covers/journal-21.png)
2021, Jun 04
Efficacy and safety of acupuncture for urinary retention after hysterectomy
Medicine
There is insufficient evidence that acupuncture can increase the patient's maximal flow rate (MFR), bladder function recovery rate (BR), and urinary tract infection rate (UIR). However, acupuncture can effectively improve the post voided residual urine (PVR), maximal cystometric capacity, and bladder capacity for first voiding desire values of patients with urinary retention after hysterectomy. Although limited due to the quality and methodological limitations of the included studies, acupuncture can still be used as an effective and safe treatment for women with urinary retention after hysterectomy.
Zhao Q, Yan C, Dan M, Jia H Full Article
![The Brazilian Journal of Nursing The Brazilian Journal of Nursing](https://clinix.io/research/journal-covers/journal-19.png)
2021, Jan
Effects of acupuncture in patients with chronic kidney disease: a systematic review
The Brazilian Journal of Nursing Brazilian Nursing Association
This study highlighted the efficacy of acupuncture for patients with chronic kidney disease. Not only does in alleviate symptoms related to kidney disease but also improve quality of life, fatigue and sleep patterns.
Melo GAA, Aguiar LL, Silva RA, Pereira FGF, Silva FLBD, Caetano JÃ. Full Article
![Frontiers in Pharmacology Frontiers in Pharmacology](https://clinix.io/research/journal-covers/journal-126.png)
2021, Nov 26
Exploring the Critical Components and Therapeutic Mechanisms of Perilla frutescens L. in the Treatment of Chronic Kidney Disease via Network Pharmacology
Frontiers in Pharmacology
Our findings revealed that luteolin can reduce renal tubular epithelial cell apoptosis and may be the critical component of P. frutescens in the treatment of CKD. It provides references and direction for further research.
Yong C, Zhang Z, Huang G, Yang Y, Zhu Y, Qian L, Tian F, Liu L, Wu Q, Xu Z, Chen C, Zhao J, Gao K, Zhou E Full Article
![Nutrients Nutrients](https://clinix.io/research/journal-covers/journal-130.png)
2021, Feb 10
Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients
Nutrients
The high MPC EVOO (Synergy) demonstrated greater and persistent improvements in renal function biomarkers, lipid profile, oxidative stress, inflammatory parameters, and body composition compared to the medium MPC EVOO (Luxolio) in nephropathic patients.
Noce A, Marrone G, Urciuoli S, Di Daniele F, Di Lauro M, Pietroboni Zaitseva A, Di Daniele N, Romani A Full Article
![BMC Urology BMC Urology](https://clinix.io/research/journal-covers/journal-869.png)
2021, Oct 19
Pumpkin seed oil (Cucurbita pepo) versus tamsulosin for benign prostatic hyperplasia symptom relief: a single-blind randomized clinical trial
BMC Urology
Pumpkin seed oil relieved BPH symptoms with no side effects, but was not as effective as tamsulosin.
Zerafatjou N, Amirzargar M, Biglarkhani M, Shobeirian F, Zoghi G Full Article
![Scientific Reports Scientific Reports](https://clinix.io/research/journal-covers/journal-26.png)
2021, Jul 08
Relationship between serum total testosterone and prostate volume in aging men
Scientific Reports
Men with low testosterone had larger prostate volume than those with normal testosterone levels, and testosterone level was negatively correlated with prostate volume.
Xia BW, Zhao SC, Chen ZP, Chen C, Liu TS, Yang F, Yan Y Full Article
![Journal of Renal Nutrition Journal of Renal Nutrition](https://clinix.io/research/journal-covers/journal-781.png)
2021, Jan
Effect of Coffee Consumption on Renal Outcome: A Systematic Review and Meta-Analysis of Clinical Studies
Journal of Renal Nutrition
Coffee consumption is associated with a significant decrease in the risk for incident CKD, ESKD, and albuminuria, as well as a lower risk of death related to CKD.
Kanbay M, Siriopol D, Copur S, Tapoi L, Benchea L, Kuwabara M, Rossignol P, Ortiz A, Covic A, Afsar B Full Article
![BJOG: An International Journal of Obstetrics & Gynaecology BJOG: An International Journal of Obstetrics & Gynaecology](https://clinix.io/research/journal-covers/journal-52.png)
2020, Jun 03
Acupuncture for recurrent urinary tract infection in women: a systematic review and metaâ€analysis
BJOG: An International Journal of Obstetrics & Gynaecology Royal College of Obstetricians & Gynaecologists
Given the growing challenge of antibiotic resistance, the chance of achieving a composite cure with acupuncture therapies was greater than that with antibiotics. Acupuncture appeared to be beneficial for treatment and prophylaxis of rUTIs.
Qin X, Coyle ME, Yang L, Liang J, Wang K, Guo X, Zhang AL, Mao W, Lu C, Xue CC, Liu X Full Article
![Evidence-Based Complementary and Alternative Medicine Evidence-Based Complementary and Alternative Medicine](https://clinix.io/research/journal-covers/journal-10.png)
2020, Oct 30
Jian-Pi-Yi-Shen Regulates EPO and Iron Recycling Protein Expressions in Anemic Rats with Chronic Kidney Disease: Accumulation of Hypoxia Inducible Factor-2α via ERK Signaling
Evidence-Based Complementary and Alternative Medicine
JPYS induces the expression of erythropoietin (EPO) through ERK-mediated HIF-2α protein accumulation and regulates systemic iron recycling, thereby promoting erythropoiesis and improving anemia in CKD.
Wang F, Yu H, Huang S, Zheng L, Zheng P, Zhang S, Li S, Chen J Full Article
![Acupuncture in Medicine Acupuncture in Medicine](https://clinix.io/research/journal-covers/journal-2.png)
2019, Dec
Acupuncture for overactive bladder in adults: a systematic review and meta-analysis
Acupuncture in Medicine British Medical Acupuncture Society
No significant differences in effectiveness or efficacy were found between acupuncture and drug or between verum and sham acupuncture, respectively. Further high-quality studies are required.
Mak TC, Chen HY, Cho WC Full Article
![Medicine Medicine](https://clinix.io/research/journal-covers/journal-21.png)
2018, Feb 23
Acupuncture for adults with overactive bladder: A systematic review and meta-analysis of randomized controlled trials
Medicine
The combined results showed that electroacupuncture (EA) may be more effective than sham electroacupuncture (sham EA) in improving the 24-hour nocturia episodes and EA may enhance tolterodine for relieving voiding symptoms and enhancing patients’ quality of life. Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes.
Zhao Y, Zhou J, Mo Q, Wang Y, Yu J, Liu Z. Full Article
![Medicine Medicine](https://clinix.io/research/journal-covers/journal-21.png)
2018, Feb 23
Acupuncture for adults with overactive bladder
Medicine
Acupuncture might have effect in decreasing the number of micturition episodes, incontinence episodes, and nocturia episodes. However, the evidence is insufficient to show the effect using acupuncture alone or the additional effect to drugs in treating OAB.
Zhao Y, Zhou J, Mo Q, Wang Y, Yu J, Liu Z Full Article
![The Journal of Internal Korean Medicine The Journal of Internal Korean Medicine](https://clinix.io/research/journal-covers/journal-294.png)
2018, Jun 30
Moxibustion for Benign Prostatic Hyperplasia: A Systematic Review and Meta-analysis
The Journal of Internal Korean Medicine The Society of Internal Korean Medicine
This meta-analysis of clinical trials suggests that moxibustion is effective intreating BPH patients. The results of this study could be applied to clinical treatment of BPH. However, additional large-scale clinical researches should be conducted.
Bae G, Lee S, Hong J, Lee I, Kim S, Choi J, Han C, Yun Y, Park S, Kwon J Full Article
![PLOS One PLOS One](https://clinix.io/research/journal-covers/journal-24.png)
2017, Apr 04
Acupuncture for benign prostatic hyperplasia: A systematic review and meta-analysis
PLOS One Public Library of Science
Statistically significant changes were observed in favor of acupuncture in moderate to severe BPH with respect to short-term follow-up endpoints. The clinical significance of these changes needs to be tested by further studies with rigorous designs and longer follow-up times.
Zhang W, Ma L, Bauer BA, Liu Z, Lu Y Full Article
![International Urogynecology Journal International Urogynecology Journal](https://clinix.io/research/journal-covers/journal-51.png)
2016, Jan 6
The role of acupuncture in managing overactive bladder; a review of the literature
International Urogynecology Journal International Urogynecological Association
Overactive bladder (OAB) affects a considerable proportion of men and women. Thus there is increasing interest in the use of alternative medicine in the form of acupuncture. This literature review indicated the benefit of acupuncture to be comparable with antimuscarinic treatment.
Forde JC, Jaffe E, Stone BV, Te AE, Espinosa G, Chughtai B. Full Article
![Evidence-Based Complementary and Alternative Medicine Evidence-Based Complementary and Alternative Medicine](https://clinix.io/research/journal-covers/journal-10.png)
2015, Jun 16
Efficacy of Acupuncture in Children with Nocturnal Enuresis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Evidence-Based Complementary and Alternative Medicine
Based on the findings of this study, we cautiously suggest that acupuncture therapy could improve the clinical efficacy. However, the beneficial effect of acupuncture might be overstated due to low methodological qualities. Rigorous high quality RCTs are urgently needed.
Lv ZT, Song W, Wu J, et al. Full Article
![Cochrane Database of Systematic Reviews Cochrane Database of Systematic Reviews](https://clinix.io/research/journal-covers/journal-8.png)
2015, Jun 4
Chinese herbal medicine for treating recurrent urinary tract infections in women
Cochrane Database of Systematic Reviews Cochrane
Evidence from seven small studies suggested that CHM as an independent intervention or in conjunction with antibiotics may be beneficial for treating recurrent UTIs during the acute phase of infection and may reduce the recurrent UTI incidence for at least six months postâ€treatment. CHM treatments specifically formulated for recurrent UTI may be more effective than herbal treatments designed to treat acute UTI. However, the small number and poor quality of the included studies meant that it was not possible to formulate robust conclusions on the use of CHM for recurrent UTI in women either alone or as an adjunct to antibiotics.
Flower A, Wang LQ, Lewith G, Liu JP, Li Q. Full Article
![Asian Journal of Andrology Asian Journal of Andrology](https://clinix.io/research/journal-covers/journal-44.png)
2013, Jun 03
Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials
Asian Journal of Andrology Asian Society of Andrology
Chinese herbal medicine was superior to Western medication in improving quality of life and reducing prostate volume. The frequency of adverse events in Chinese herbal medicine was similar to that of placebo and less than that of Western medication.
Ma CH, Lin WL, Lui SL, Cai XY, Wong VT, Ziea E, Zhang ZJ Full Article
![Yin Tang]( /images/acupuncture-yintang.jpg)
“It is by virtue of the twelve channels that human life exists, that disease arises, that human beings can be treated and illness cured. The twelve channels are where beginners start and masters end.” The Classic of Acupuncture
Circa 1st Century BCE