2022 International Journal of Molecular Sciences

Two varieties of chrysanthemum have similar therapeutic effects but operate through distinct mechanisms, revealing potential for precise applications in both traditional and modern medicine.

The study combined network pharmacology, molecular pharmacology, and metabolomics to clarify differences between two herbs, CMF and CIF. An initial analysis was carried out via HPLC-Q-TOF-MS which revealed distinct flavonoid constituents between CMF and CIF. These findings led researchers to make predictions about the possible biological processes responsible for the therapeutic effects of these herbs on LFHSH, including their influence on inflammatory response and fatty acid production.

Through a series of ELISA, molecular docking, Western blot, and metabolomics techniques, the research identified similar influences of CMF and CIF on blood pressure and resistance to tissue, organ and functional damage as well as dyslipidemia. Despite the similar outcomes, there was variation in their mechanism of action. Namely, these herbs uniquely influenced inflammatory response, various signaling pathways, lipid anabolism, the renin-angiotensin system, and metabolic abnormalities. Differing effects were believed to be due to each herb's unique regulatory capabilities which, despite the end effect similarities, offer unique pathways for effective medical application.

Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses Wang Y, Li Y, Guo W, Yang X, Qu J, Gao M, Chen S, Dong J, Li Q, Wang T

2022 Reference Series in Phytochemistry

Coconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention.

The study utilized comprehensive analysis to assess the chemical profile of coconut water, identifying a range of components including phytohormones, enzymes, antioxidant compounds, vitamins, minerals, and phenolic compounds. These components are known to contribute to the water's biological activity and pharmacological effects, thereby enabling a raft of medicinal properties inherent to coconut water. The water was found to feature anti-microbial, anti-bacterial, anti-inflammatory, anti-hypertensive, rejuvenating, hepatoprotective, hypolipidemic, and diuretic properties.

An examination of the therapeutic effects of coconut water revealed a significant impact on gastric dysfunction, dysentery, and child malnutrition alongside notable capabilities to manage hypertension. The water was found to promote exercise performance, reduce swelling, dissolve kidney stones, improve kidney function, improve digestion, relieve constipation, reduce the risk of heart disease, lower high blood pressure, and improve cholesterol levels. Consumption of tender coconut water was specifically found to reduce the risk of heart disease, help prevent Alzheimer’s disease pathologies and prevent osteoporosis in experimental animals. The unique nutritional profile of coconut water was also found to provide it with the capacity to balance body chemistry and fight cancer.

Health Benefits of Coconut Water Rethinam P, Krishnakumar V

2021 International Journal of Molecular Sciences

Isoflavones found in soybeans can reduce risks of certain cancers and alleviate menopause-related symptoms among women, such as vasomotor syndromes, spinal bone loss, and hypertension.

The study overviewed soybeans' chemical composition and focused mainly on isoflavones. The research examined the processes of soybean preparation that includes cleaning, drying, crushing, and dehulling, and extraction methods to derive various soy products, particularly focusing on isoflavones - daidzein, genistein, and S-equol. Various soy products such as refined soy oil, soy lecithin, free fatty acids, glycerol, and soybean meal were discussed, along with the presence of the minor biological constituents in remaining components.

The study explored the relationship between isoflavone consumption and disease prevention, particularly in relation to heart disease, cancer incidence—of the breast, bladder, and endometrial and colorectal—and menopause-related symptoms. The therapeutic effects of isoflavones were studied in the context of vasomotor syndromes, spinal bone loss, hypertension regulation, depressive symptoms during pregnancy, and in vitro glycemic control. In contrast, it failed to find definitive effects of isoflavones on cognition improvement and urogenital symptoms. The inconsistencies in defining the ingredients, doses, study durations, and outcomes of isoflavone studies proved challenging for the research.

Utilization of Isoflavones in Soybeans for Women with Menopausal Syndrome: An Overview Chen LR, Chen KH

2020 Endocrine, Metabolic & Immune Disorders - Drug Targets

Cinnamon supplementation has favorable effects on diastolic blood pressure and long-term effects on systolic blood pressure.

Out of 927 records, 8 trials that enrolled 582 participants were included. The pooled effect size showed that systolic blood pressure did not change following cinnamon supplementation. Also cinnamon supplementation in long-duration (≥ 8weeks) had a significant effect on systolic blood pressure. Pooled analysis showed that cinnamon had a significant effect on diastolic blood pressure. In addition, results from both duration subsets and high dose (>1500 mg/day) of cinnamon supplementation were significant.

What is the Impact of Cinnamon Supplementation on Blood Pressure? A Systematic Review and Meta-Analysis Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-Sahlabadi A, Hosseini SA.

2020 Clinical Nutrition ESPEN

Cinnamon supplementation can improve blood pressure by a modest degree.

Meta-analysis of 9 RCTs with 641 participants showed significant reductions in both systolic (WMD: −5.17 mmHg, 95% CI: −9.35 to −0.99, P = 0.01) and diastolic blood pressure (WMD: −3.36 mmHg, 95% CI: −5.67 to −1.04, P ≤ 0.001) after cinnamon supplementation. Subgroup analyses indicated that these results were significant only when cinnamon was administered at the dosages of ≤2 g/day, for a period longer than 8 weeks, and in participants with a baseline BMI of ≥30 kg/m2.

The effect of cinnamon supplementation on blood pressure in adults: A systematic review and meta-analysis of randomized controlled trials Hadi A, Campbell MS, Hassani B, Pourmasoumi M, Salehi-sahlabadi A, Hosseini SA

2020 Medicine

Green tea intake can significantly reduce both systolic and diastolic blood pressure.

In this meta-analysis, studies were sourced from the PubMed, Embase, and Cochrane Library databases from their inception to August 2019. The selection criteria focused on randomized placebo-controlled trials, exploring the effects of green tea on blood pressure control. The final selection consisted of twenty-four trials involving 1697 subjects, and the results were pooled using the generic inverse-variance method with random-effects weighting. The quality of the included studies was independently ascertained using the Jadad score, while potential publication bias was evaluated using funnel plots, and the Egger and Begg tests.

The pooled results showed that green tea intake led to notable reductions in both systolic and diastolic blood pressure, though the outcomes revealed significant heterogeneity among the trials. The funnel plots and tests used to investigate the publication bias did not find any substantial evidence to suggest this was an influencing factor in the results.

Effect of green tea supplementation on blood pressure Xu R, Yang K, Ding J, Chen G

2019 Critical Reviews in Food Science and Nutrition

Cinnamon supplementation leads to a significant reduction in both systolic and diastolic blood pressure in adults.

This systematic review and meta-analysis included studies up to July 2019, sourced from databases like PubMed/Medline, Scopus, ISI Web of Science, Embase, and Google Scholar. The research focused on randomized clinical trials that primarily explored the effect of oral cinnamon supplementation on blood pressure parameters, including systolic or diastolic blood pressure.

From the 469 citations, nine trials involving 641 subjects were included. The results inferred that cinnamon supplementation leads to a noticeable decrease in both systolic and diastolic blood pressure. A more remarkable effect on systolic blood pressure was observed in trials using less or equal to 2g cinnamon, lasting for 12 weeks or more, and included participants under the age of 50. Diastolic blood pressure was also reduced using lower doses of cinnamon. No significant non-linear associations were detected between cinnamon supplementation dosage, study duration, and both systolic and diastolic blood pressure.

Anti-hypertensive effects of cinnamon supplementation in adults: A systematic review and dose-response Meta-analysis of randomized controlled trials Seyed Mohammad Mousavi, Ahmad Jayedi, Yahya Jalilpiran, Maryam Hajishafiee, Azadeh Aminianfar, Ahmad Esmaillzadeh.

2019 Journal of Sleep Research

Acupuncture therapy does not impact the severity of Obstructive Sleep Apnea, blood pressure, or quality of life in hypertensive patients.

The study examined the effects of acupuncture on blood pressure and Obstructive Sleep Apnea severity in hypertensive patients. These patients, all suffering from mild to moderate Obstructive Sleep Apnea, were randomly divided into two groups, one of which received acupuncture treatment while the other received sham-acupuncture treatment, essentially a placebo. Each patient's condition was assessed before and after ten acupuncture sessions, relying on measures such as polysomnography, around-the-clock blood pressure monitoring, and a life quality survey.

A total of 44 patients completed the study, the group covering both genders, with an average age of 57 years, and a diverse range of body mass indices and apnea-hypopnea indices. It's important to note that there were no distinguishable differences observed in the apnea-hypopnea index, daytime or nighttime blood pressure, or life quality between the group that received genuine acupuncture treatment and the group that received the placebo treatment.

Effects of acupuncture on obstructive sleep apnea severity, blood pressure control and quality of life in patients with hypertension: A randomized controlled trial Silva MVFP, Lustosa TC, Arai VJ, Couto Patriota TLG, Lira MPF, Lins‐Filho OL, Chalegre ST, B.B.A.S. K, Secundo IV, Pedrosa RP

2015 PLOS One

There is evidence of efficacy of acupuncture as an adjunctive therapy to western medicine for treating hypertension.

Our review provided evidence of acupuncture as an adjunctive therapy to medication for treating hypertension, while the evidence for acupuncture alone lowing BP is insufficient. The safety of acupuncture is uncertain due to the inadequate reporting of it. However, the current evidence might not be sufficiently robust against methodological flaws and significant heterogeneity of the included RCTs. Larger high-quality trials are required.

Is Acupuncture Effective for Hypertension? A Systematic Review and Meta-Analysis Zhao XF, Hu HT, Li JS, Shang HC, Zheng HZ, Niu JF, et al